Identification of different Robertsonian translocations in man by quinacrine mustard fluorescence analysis
نویسندگان
چکیده
منابع مشابه
Robertsonian Translocations: An Overview of 872 Robertsonian Translocations Identified in a Diagnostic Laboratory in China
Robertsonian translocations (ROBs) have an estimated incidence rate of 1/1000 births, making this type of rearrangement the most common structural chromosomal abnormalities seen in the general population. In this study, we reports 872 cases of ROBs from 205,001 specimens karyotyped postnatally in a single accredited laboratory in China, including 583 balanced ROBs, 264 unbalanced ROBs, 9 mosaic...
متن کاملMicro-Evolution in Grasshoppers Mediated by Polymorphic Robertsonian Translocations
This review focuses on grasshoppers that are polymorphic for Robertsonian translocations because in these organisms the clarity of meiotic figures allows the study of both chiasma distribution and the orientation of trivalents and multivalents in metaphase I. Only five species of such grasshoppers were found in the literature, and all of them were from the New World: Oedaleonotus enigma (Scudde...
متن کاملPGD in female carriers of balanced Robertsonian and reciprocal translocations by first polar body analysis.
Preimplantation genetic diagnosis (PGD) using the first polar body (1PB) is a modality of PGD that can be used when the woman is the carrier of a genetic disease or of a balanced chromosomal reorganization. PGD using 1PB biopsy in carriers of balanced chromosome reorganizations has not become generalized. Here, we describe our experience based on the analysis of unfertilized or fresh, non-insem...
متن کاملCattanach's translocation: cytological characterization by quinacrine mustard staining.
Metaphase chromosomes of mice carrying Cattanach's translocation, which is the deletion of material from a medium-sized autosome and its insertion into an X chromosome, were stained with quinacrine mustard. Comparison of the fluorescence patterns of these chromosomes with those of the chromosomes of normal mice has allowed the identification of the autosome involved in the translocation and loc...
متن کاملAn unusual case of mosaic Down's syndrome involving two different Robertsonian translocations.
A baby girl with some of the stigmata of Down's syndrome was found to be a mosaic with three different cell lines: 45,XX,-13,-21,+t(13q21q)/(46,XX/46,XX, -21,+t(21q21q). The chromosome rearrangements detected in this patient appear to have arisen de novo. In the normal cell line the terminal end of the p arm of one chromosome 21 is thought to have been damaged. It seems probable that this is re...
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ژورنال
عنوان ژورنال: Hereditas
سال: 2009
ISSN: 0018-0661
DOI: 10.1111/j.1601-5223.1971.tb02375.x